What condition is indicated by hypotonia, upslanting palpebral fissures, bilateral epicanthal folds, macroglossia, and a single transverse palmar crease in an infant?

The described condition encompasses a range of characteristic features that align with Trisomy 21, also known as Down syndrome. Hypotonia, or decreased muscle tone, is commonly noted in infants with Down syndrome and is a key reflecting factor in developmental assessments. Upslanting palpebral fissures, which cause the eyes to appear slanted, and bilateral epicanthal folds are frequently observed facial features in these infants.

Moreover, macroglossia, or an enlarged tongue, and a single transverse palmar crease are both classic physical markers indicative of Down syndrome. The presence of a single transverse palmar crease, often referred to as a "simian line," adds to the list of clinical signs. Combined, these indicators form a recognizable pattern associated with Trisomy 21, making it the most likely diagnosis among the presented options.

Turner syndrome typically involves features such as short stature and abnormalities in sex chromosome formation, Klinefelter syndrome is characterized by additional X chromosomes in males, often leading to height and reproductive issues, and Edward syndrome is associated with a different set of physical abnormalities, including a small head and clenched fists, which do not match the described features. Thus, the comprehensive combination of symptoms strongly points to Tr